Presynaptic mGluRs Control the Duration of Endocannabinoid-Mediated DSI
نویسندگان
چکیده
منابع مشابه
Interneuron activity controls endocannabinoid-mediated presynaptic plasticity through calcineurin.
Retrograde signaling by endocannabinoids (eCBs) mediates a widely expressed form of long-term depression at excitatory and inhibitory synapses (eCB-LTD), involving a reduction in neurotransmitter release. In the hippocampus, eCB-LTD occurs at interneuron (IN)-pyramidal cell (PC) synapses (I-LTD), and its induction requires a presynaptic reduction of cAMP/PKA signaling resulting from minutes of ...
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5 Endogenous cannabinoids (eCBs) mobilized from postsynaptic cells activate presynaptic cannabinoid 6 receptors (CB1Rs), and thereby inhibit synaptic transmitter release. The inhibition can be either brief 7 (seconds) or long-lasting (minutes to hours). Recent studies provide insight into the presynaptic 8 mechanisms responsible for long-lasting, eCB-mediated long-term depression (eCB-LTD). Amo...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 2018
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.1097-18.2018